2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Drug Metabolite

Drug Metabolite

Drug Metabolite

Related Products

PDF 3.95 MB

Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Cat. No. 상품명 효과 Purity Chemical Structure
  • HY-W004298
    10-Undecen-1-ol
    		99.56%
    10-Undecen-1-ol, converted from ricinoleic acid, can be used as a comonomer for the introduction of functional groups.
    10-Undecen-1-ol
  • HY-B1109
    N-Acetylprocainamide
    		99.89%
    N-Acetylprocainamide is a class III antiarrhythmic, which blocks K+ channels.
    N-Acetylprocainamide
  • HY-100646A
    (Z)-10-Hydroxynortriptyline
    		99.72%
    (Z)-10-Hydroxynortriptyline is a metabolite of Nortriptyline. Nortriptyline is a tricyclic antidepressant and the main active metabolite of Amitriptyline, and is used to relieve the symptoms of depression.
    (Z)-10-Hydroxynortriptyline
  • HY-16445B
    CNDAC hydrochloride
    		98.01%
    CNDAC hydrochloride is a metabolite of the orally active agent Sapacitabine (HY-16445), and a nucleoside analog. CNDAC hydrochloride induces DNA damage and apoptosis.
    CNDAC hydrochloride
  • HY-130239
    14(S)-HDHA
    		98.02%
    14(S)-HDHA (14(S)-HDoHE) is an oxygenation product of Docosahexaenoic acid (DHA). 14(S)-HDHA is a marker reflecting activation of a Docosahexaenoic acid carbon 14-lipoxygenation pathway.
    14(S)-HDHA
  • HY-B1984
    p,p'-DDD
    		99.37%
    p,p'-DDD (4,4’-DDD) is an organochlorine insecticide, a major metabolite of p,p'-DDT. p,p'-DDD is an agonist at estrogen receptor α(ERα) and ERβ. p,p'-DDD increases DNA damage, apoptosis and necrosis in peripheral blood. p,p'-DDD stimulates cell proliferation in SKBR3 cells. p,p'-DDD activates the AP-1 transcription factor. p,p'-DDD decreases sleep times of barbiturates and steroids in rats.
    p,p'-DDD
  • HY-N0917
    6''-O-Malonylgenistin
    		99.04%
    6''-O-Malonylgenistin (Malonylgenistin) is a glycosylated isoflavone and metabolite of Genistin (HY-N0595). 6''-O-Malonylgenistin activates hTAS2R39. 6''-O-Malonylgenistin can be used in the research of bitter taste.
    6''-O-Malonylgenistin
  • HY-W014632
    4-Trifluoromethylsalicylic acid
    		99.93%
    4-Trifluoromethylsalicylic acid (Desacetyl triflusal) is a platelet aggregation inhibitor.
    4-Trifluoromethylsalicylic acid
  • HY-133980A
    O-Demethyl Lenvatinib hydrochloride
    O-Demethyl Lenvatinib hydrochloride is a metabolite of Lenvatinib (HY-10981). Lenvatinib (E7080) is an oral, multi-targeted tyrosine kinase inhibitor that inhibits VEGFR1-3, FGFR1-4, PDGFR, KIT, and RET. Lenvatinib shows potent antitumor activities.
    O-Demethyl Lenvatinib hydrochloride
  • HY-135359
    RP 48497
    		99.79%
    RP 48497, an impurity of Eszopiclone, is a photodegradation product of Eszopiclone. Eszopiclone is a non-benzodiazepine agent used in the treatment of insomnia.
    RP 48497
  • HY-118133
    4'-Hydroxy flurbiprofen
    		99.28%
    4'-Hydroxy flurbiprofen is an oxidative metabolite of Flurbiprofen (HY-10582) via the cytochrome P450 enzyme system. 4'-Hydroxy flurbiprofen inhibits COX-1 by 94% at a concentration of 1000 µM.
    4'-Hydroxy flurbiprofen
  • HY-W016388
    9-Fluorenol
    		99.98%
    9-Fluorenol (9-Hydroxyfluorene; compound 3) is a dopamine (DAT) inhibitor with IC50 value of 9 µM. 9-Fluorenol is a major metabolite of compound developed as a wake promoting agent. 9-Fluorenol shows wake promotion activity in vivo.
    9-Fluorenol
  • HY-133676
    Mono(2-ethyl-5-oxohexyl) phthalate
    		99.59%
    Mono (2-ethyl-5-oxohexyl) phthalate (5-oxo-MEHP) is an oxidative metabolite of Di (2-ethylhexyl) phthalate (DEHP) . Mono (2-ethyl-5-oxohexyl) phthalate may protective sperm DNA damage. Di (2-ethylhexyl) phthalate is the predominant plasticizer added to rigid polyvinyl chloride (PVC) to impart flexibility, temperature tolerance, optical clarity, strength and resistance to kinking.
    Mono(2-ethyl-5-oxohexyl) phthalate
  • HY-G0014A
    Quetiapine sulfoxide dihydrochloride
    		98.63%
    Quetiapine sulfoxide dihydrochloride (Quetiapine S-oxide dihydrochloride) is a main metabolite of Quetiapinem. Quetiapine is a second-generation antipsychotic. Quetiapine is a 5-HT receptors agonist and a dopamine receptor antagonist.
    Quetiapine sulfoxide dihydrochloride
  • HY-133624
    1,1,3-Tribromoacetone
    		98.0%
    1,1,3-Tribromoacetone is an impurity of Methotrexate (HY-14519). Methotrexate, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis.
    1,1,3-Tribromoacetone
  • HY-129072
    Isocyclosporin A
    		99.05%
    Isocyclosporin A is a degradation product of the immunosuppressant Cyclosporin A.
    Isocyclosporin A
  • HY-136436A
    Ternidazole
    		99.11%
    Ternidazole is a nitroimidazole Antibiotic with anti-pathogenic microbial activity. Ternidazole kills and inhibits the visible growth of Clostridium perfringens type A in vitro. Ternidazole helps improve the therapeutic efficacy against bacterial vaginosis, candidal vaginitis and mixed vaginitis. Ternidazole effectively alleviates chronic alcoholism. Ternidazole can be used in research related to vaginitis, pathogenic microbial infections and chronic alcoholism.
    Ternidazole
  • HY-113499B
    cis-Malonylcarnitine lithium
    		98.3%
    cis-Malonylcarnitine lithium is an ester compound and a metabolite of Malonyl CoA (HY-115899). The level of cis-Malonylcarnitine lithium is closely related to some diseases, such as malonic aciduria, non-syndromic cleft lip with or without cleft palate, etc.
    cis-Malonylcarnitine lithium
  • HY-I0169
    (R)-Amino-N-benzyl-3-methoxypropionamide
    		99.95%
    (R)-Amino-N-benzyl-3-methoxypropionamide is a key intermediate for the synthesis of the antiepileptic agent (R)-Lacosamide. To improve its chiral purity and chemical stability, (R)-Amino-N-benzyl-3-methoxypropionamide can react with phosphoric acid to form a phosphate salt. Detected by high performance liquid chromatography (HPLC), this phosphate salt exhibits extremely high chiral purity, with the content of the R-enantiomer reaching up to 99.37%.
    (R)-Amino-N-benzyl-3-methoxypropionamide
  • HY-G0023
    Niraparib metabolite M1
    		99.51%
    Niraparib metabolite M1 is a metabolite of niraparib, and the latter one acts as a novel poly(ADP-Ribose) polymerase (PARP) inhibitor.
    Niraparib metabolite M1
Cat. No. 상품명 / Synonyms Application Reactivity